Detailed view for PVX_099705

Basic information

TDR Targets ID: 265651
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 8.1998 | Length (AA): 1413 | MW (Da): 158862 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13576   Pentapeptide repeats (9 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005488   binding  
GO:0016070   RNA metabolic process  

Metabolic Pathways

RNA transport (KEGG)
mRNA surveillance pathway (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
42 227 4uos (A) 1 187 11.00 0.13 0.09 0.278535 -0.91
162 207 4nfn (A) 279 314 28.00 0.053 0.03 -0.172345 1.91
607 874 4cek (A) 458 757 23.00 0 1 0.442767 -0.7
677 878 2vso (E) 582 853 11.00 0.00035 0.65 0.224058 -0.83
752 912 4uos (A) 6 161 28.00 0.064 0.74 0.319842 -0.06
896 1227 1uw4 (B) 768 1006 21.00 0 1 -0.0559389 0.94
897 1047 1uw4 (B) 769 918 22.00 0.91 0.91 0.445765 -0.81
970 1269 4k1p (C) 43 352 9.00 0.28 0 0.195214 0.54
1114 1339 4tql (A) 10 239 9.00 0.00011 0.01 0.165843 -0.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_158770)

Species Accession Gene Product
Plasmodium berghei PBANKA_0826600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0925800   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0723700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_099705   hypothetical protein, conserved
Plasmodium yoelii PY03876   TAP1 protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PVX_099705 (Plasmodium vivax), hypothetical protein, conserved
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